Research & Clinical Trials : Scientific Publications

Scientific Publications

The investigators associated with the Interdisciplinary Stem Cell Institute publish regularly in scientific journals. Listed below are select, recently published scientific articles.

Hematology and Cancer

Kim TK, Billard MJ, Wieder ED, McIntyre BW, Komanduri KV. Co-engagement of alpha(4)beta(1) integrin (VLA-4) and CD4 or CD8 is necessary to induce maximal Erk1/2 phosphorylation and cytokine production in human T cells. Human Immunology 2010, 71(1):23-8. PMID: 19815047.

Hatzistergos KE, Blum A, Ince T, Grichnik JM, Hare JM. What is the oncologic risk of stem cell treatment for heart disease? Circulation Research 2011, 108(11):1300-3. PMID: 21617132.

Lin MC, Lomo L, Baak JP, Eng C, Ince TA, Crum CP, Mutter GL. Squamous morules are functionally inert elements of premalignant endometrial neoplasia. Modern Pathology 2009, 22(2):167-74. PMID: 19180120.

Wang Y, Nathanson L, McNiece IK. Differential hematopoietic supportive potential and gene expression of stromal cell lines from midgestation mouse placenta and adult bone marrow. Cell Transplantation. 2010 Nov 5. [Epub ahead of print] PMID: 21054929.


Goldschmidt-Clermont PJ, Seo DM, Wang L, Beecham GW, Liu ZJ, Vazquez-Padron RI, Dong C, Hare JM, Kapiloff MS, Bishopric NH, Pericak-Vance M, Vance JM, Velazquez OC. Inflammation, stem cells and atherosclerosis genetics. Curr Opin Mol Ther. 2010 Dec;12(6):712-23. Review. PMID: 21154163.

Ghersin E, Soto V, Heldman AW. Multidetector computerized tomography can guide and document alcohol septal ablation in hypertrophic obstructive cardiomyopathy. Circulation 2011, 123(2):e5-7. PMID: 21242503.

Hatzistergos KE, Quevedo HC, Oskouei BN, Hu Q, Feigenbaum GS, Margitich IS, Mazhari R, Boyle AJ, Zambrano JP, Rodriguez JE, Dulce RA, Pattany PM,Valdes D, Revilla C, Heldman AW, McNiece I, Hare JM. Bone marrow Mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circulation Research 2010,107;913-22. PMID: 20671238.

Heidecker B, Kittleson MM, Kasper EK, Wittstein IS, Champion HC, Russell SD, Hruban RH, Rodriguez ER, Baughman KL, Hare JM. Transcriptomic biomarkers for the accurate diagnosis of myocarditis. Circulation 2011, 123(11):1174-84. PMID: 21382894.

Heldman AW, Zambrano JP, Hare JM. Cell therapy for heart disease: where are we in 2011? Journal American College of Cardiology 2011, 57(4):466-8. PMID: 21251588.

Kanashiro-Takeuchi RM, Schulman IH, Hare JM. Pharmacologic and genetic strategies to enhance cell therapy for cardiac regeneration. Journal of Molecular and Cellular Cardiology 2011 May 30. [Epub ahead of print] PMID: 21645519.

Li, J., Negro, A., Lopez, J., Bauman, A.L., Henson, E., Dodge-Kafka, K.L., and Kapiloff, M.S. The mAKAP Scaffold Regulates Cardiac Myocyte Hypertrophy via Recruitment of Activated Calcineurin. Journal of Molecular and Cellular Cardiology 2010, 48(2):387-94. PMID: 19883655.

Mushtaq M, Oskouei BN, Hare JM. Cell therapy for heart disease: to genetically modify or not, that is the question. Circulation Research. 2011 Feb 18;108(4):398-401. PMID: 21335427.

Norton N, Li D, Rieder MJ, Sieg fried JD, Rampersaud E, Zuchner S, Mangos S, Gonzalez-Quintana J, Wang L, McGee S, Reiser J, Martin E, Nickerson DA, and Hershberger RE. Genome-wide Studies of Copy Number Variation and Exome Sequencing Identify Rare Variants in BAG3 as a Cause of Dilated Cardiomyopathy. The American Journal of Human Genetics 2011, 88(3):273-82. PMID: 21353195.

Rodrigues, C. O., Nerlick, S., White, E. L., Cleveland J. L., and King, M. L. A Myc-Twist-Slug Regulatory Circuit Directs Vascular Development. Development 2008, 135:1903-1911. PMID: 18469221.

Trachtenberg B, Velazquez DL, Williams AR, McNiece I, Fishman J, Nguyen K, Rouy D, Altman P, Schwarz R, Mendizabal A, Oskouei B, Byrnes J, Soto V, Tracy M, Zambrano JP, Heldman AW, Hare JM. Rationale and design of the Transendocardial Injection of Autologous Human Cells (bone marrow or mesenchymal) in Chronic Ischemic Left Ventricular Dysfunction and Heart Failure Secondary to Myocardial Infarction (TAC-HFT) trial: A randomized, double-blind, placebo-controlled study of safety and efficacy. American Heart Journal 2011, 161(3):487-93. PMID: 21392602.

Williams, AR, Trachtenberg B, Velazquez DL, McNiece I, Altman P, Rouy D, Mendizabal AM, Pattany PM, Lopera GA, Fishman J, Zambrano JP, Heldman AW, Hare JM. Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: Functional recovery and reverse remodeling. Circulation Research 2011, 108:792-296. PMID: 21415390

Zhu S, Malhotra A, Zhang L, Deng S, Zhang T, Freedman NJ, Storms R, Peppel K, Goldschmidt-Clermont PJ, and Dong C. Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice. Atherosclerosis 2010, 212 (1):639. PMID: 20451204


Badiavas EV, Ford D, Liu P, Kouttab N, Morgan J, Richards A, Maizel A: Long term bone marrow culture and its clinical potential in chronic wound healing. Wound Repair Regeneration 2007, 15(6):856-865. PMID: 18028134

Grichnik JM. Melanoma, Nevogenesis, and Stem Cell Biology, Journal of Investigative Dermatology 2008, 128(10):2365-80. PMID: 18787546

Kowalczyk J and Badiavas EV: Bone Marrow Adult Stem and Progenitor Cells in the Treatment of Chronic Wounds. Advances in Wound Care 2010, (1) 490-494.

Shao H, Cai L, Grichnik JM, Livingstone AS, Velazquez OC, Liu ZJ. Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1. Oncogene. 2011 Apr 25. PMID: 21516124.


Kunzevitzky NJ, Almeida MV, Duan Y, Li S, Xiang M, Goldberg JL. Foxn4 is required for retinal ganglion cell distal axon patterning. Mol Cell Neurosci. 2011 Apr;46(4):731-41. PMCID: PMC3081519.PMID: 21334440.

Moore DL, Apara A, Goldberg JL.Krüppel-like transcription factors in the nervous system: Novel players in neurite outgrowth and axon regeneration. Mol Cell Neurosci. 2011 May 24. [Epub ahead of print] PMID: 21635952.

Moore DL, Goldberg JL. Multiple transcription factor families regulate axon growth and regeneration. Dev Neurobiol. 2011 Jun 14. [Epub ahead of print] PMID: 21674813.

Moore DL, Blackmore MG, Hu Y, Kaestner KH, Bixby JL, Lemmon VP, Goldberg JL. KLF Family Members Regulate Intrinsic Axon Regeneration Ability. Science 2009, 326(5950):298-301. PMCID: PMC2882032. PMID: 19815778.